John S Lazo Selected Research

2,3- bis(2- hydroxyethylsulfanyl)- (1,4)naphthoquinone

1/2004	Activation of the Raf-1/MEK/Erk kinase pathway by a novel Cdc25 inhibitor in human prostate cancer cells.
4/2002	Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

John S Lazo Research Topics

Disease

52	Neoplasms (Cancer) 01/2021 - 01/2003
6	Prostatic Neoplasms (Prostate Cancer) 01/2016 - 01/2004
6	Carcinogenesis 01/2013 - 04/2002
5	Glioblastoma (Glioblastoma Multiforme) 12/2012 - 10/2009
4	Cutaneous Leishmaniasis 12/2021 - 11/2009
4	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 01/2005
3	Leishmaniasis 12/2021 - 11/2009
3	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 02/2018
3	Neoplasm Metastasis (Metastasis) 12/2020 - 01/2013
3	Breast Neoplasms (Breast Cancer) 12/2019 - 06/2011
3	Lung Neoplasms (Lung Cancer) 08/2010 - 02/2003
2	Hematologic Neoplasms (Hematological Malignancy) 12/2020 - 01/2018
2	Squamous Cell Carcinoma of Head and Neck 09/2015 - 01/2014
2	Acquired Immunodeficiency Syndrome (AIDS) 01/2013 - 11/2009
2	Colonic Neoplasms (Colon Cancer) 01/2013 - 10/2009
2	Glioma (Gliomas) 01/2010 - 12/2009
2	Hepatocellular Carcinoma (Hepatoma) 02/2003 - 05/2002
1	Acute Lung Injury 01/2021
1	Body Weight (Weight, Body) 01/2021
1	Lung Injury 01/2021
1	Frontotemporal Dementia (Semantic Dementia) 01/2020
1	Colorectal Neoplasms (Colorectal Cancer) 10/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2018
1	Amyloid Plaque 01/2018
1	Pathologic Processes 05/2014
1	Pathologic Neovascularization 02/2014
1	Conjunctivitis 01/2014
1	Seasonal Allergic Rhinitis (Hay Fever) 01/2014
1	Vasomotor Rhinitis 01/2014
1	Adenocarcinoma 10/2012

Drug/Important Bio-Agent (IBA)

18	Pharmaceutical PreparationsIBA 12/2021 - 11/2009
14	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2003
11	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 01/2007
11	Protein Tyrosine PhosphatasesIBA 12/2020 - 02/2003
8	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 12/2019 - 01/2003
7	Biological ProductsIBA 01/2019 - 10/2005
7	Small Interfering RNA (siRNA)IBA 12/2012 - 12/2009
6	JMS-053IBA 01/2021 - 02/2018
5	Dual-Specificity PhosphatasesIBA 01/2021 - 04/2002
5	Tyrosine (L-Tyrosine)FDA Link 05/2014 - 02/2003
4	Oncogene Proteins (Oncogene Protein)IBA 02/2018 - 09/2003
4	DNA (Deoxyribonucleic Acid)IBA 08/2010 - 05/2005
3	Messenger RNA (mRNA)IBA 01/2013 - 02/2003
3	Paclitaxel (Taxol)FDA LinkGeneric 06/2011 - 02/2008
3	Phosphotransferases (Kinase)IBA 12/2009 - 01/2004
3	cdc25 PhosphatasesIBA 10/2009 - 01/2004
3	Mitogen-Activated Protein KinasesIBA 08/2006 - 01/2004
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2021 - 01/2014
2	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 10/2005
2	CytokinesIBA 01/2021 - 01/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2019 - 09/2005
2	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 12/2019 - 01/2018
2	Drug CombinationsIBA 01/2018 - 12/2011
2	AndrogensIBA 01/2016 - 01/2004
2	Interleukin-6 (Interleukin 6)IBA 09/2015 - 01/2014
2	CarcinogensIBA 01/2013 - 02/2003
2	LigandsIBA 10/2012 - 02/2005
2	Vinblastine (Vinblastine Sulfate)FDA Link 12/2011 - 02/2010
2	Phorbol EstersIBA 01/2011 - 11/2008
2	furanIBA 01/2011 - 06/2009
2	protein kinase DIBA 12/2010 - 05/2010
2	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2009 - 03/2007
2	EnzymesIBA 03/2009 - 04/2002
2	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideIBA 10/2007 - 02/2003
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 09/2007 - 09/2006
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 03/2007 - 01/2004
2	2,3- bis(2- hydroxyethylsulfanyl)- (1,4)naphthoquinoneIBA 01/2004 - 04/2002
1	SARS-CoV-2 spike proteinIBA 01/2021
1	Serum AlbuminIBA 12/2020
1	Human Serum Albumin FDA LinkGeneric 12/2020
1	elastin microfibril interface located protein (emilin)IBA 10/2018
1	Insulin (Novolin)FDA Link 01/2018
1	Amyloid (Amyloid Fibrils)IBA 01/2018
1	Androgen Receptors (Androgen Receptor)IBA 01/2016
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2016
1	abirateroneIBA 01/2016
1	enzalutamideIBA 01/2016
1	TriterpenesIBA 10/2015
1	celastrolIBA 10/2015
1	Transcription Factor 3IBA 09/2015
1	GoldIBA 03/2014
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2014
1	azelastine (Optivar)FDA LinkGeneric 01/2014
1	Transcription Factors (Transcription Factor)IBA 01/2014
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2014
1	Adenosine Monophosphate (AMP)IBA 01/2014
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2014
1	ColforsinIBA 01/2014
1	Histamine H1 Receptors (Histamine H1 Receptor)IBA 01/2014
1	AzoxymethaneIBA 01/2013
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2013
1	Dextrans (Dextran)FDA Link 01/2013
1	Alkylating AgentsIBA 12/2012
1	Temozolomide (Temodar)FDA LinkGeneric 12/2012
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2012
1	GlucocorticoidsIBA 10/2012

Therapy/Procedure

13	Therapeutics 01/2021 - 12/2007
3	Drug Therapy (Chemotherapy) 12/2012 - 10/2009
2	Radiotherapy 01/2011 - 10/2009
1	Castration 01/2016